Posted on March 10, 2010.
Treatment of mesothelioma cancer. Heated intraoperative intraperitoneal chemotherapy A procedure known as heated intraoperative intraperitoneal chemotherapy was developed by Paul Sugarbaker at the Washington Cancer Institute.The surgeon removes as much tumor as possible followed by the direct administration of a chemotherapy agent, heated to between 40 and 48 C, in the abdomen. The fluid is perfused for 60 to 120 minutes, then drained.
This technique allows the administration of high concentrations of certain drugs in abdominal and pelvic surfaces. Heating the chemotherapy increases the penetration of drugs into tissues. In addition, heating itself damages the malignant cells than normal cells.
Dr. Paul Sugarbaker, renowned surgeon specializing in oncology at the Institute of mesothelioma cancer Washington, developed an advanced surgical procedure to treat mesothelioma called heated intraoperative intraperitoneal chemotherapy. In this procedure, both the tumor as possible is first removed by a surgeon. After removal of the tumor, chemotherapy agent heated to between 40 ° C and 48 ° C is administered in the abdomen. The fluid is perfused for anywhere between one and two hours, then it is drained.
High concentrations of certain drugs can be administered in the abdominal and pelvic surfaces using this technique. Another advantage associated with using this technique to treat peritoneal mesothelioma is that the heated chemotherapy increases the level at which drugs can penetrate tissues and malignant cells in damages of more than normal.
Coliseum technique for intraoperative intraperitoneal hyperthermic chemotherapy
cytoreductive surgery has been attempted to make each patient macroscopically free of disease. At the end of the procedure, four closed suction catheters (Zimmer Inc., Warsaw, IN) were placed through the abdominal wall, using incisions, to lie under each hemidiaphragm and two in the pelvis (Figure 2). A Tenckhoff catheter (Quinton Inc., Seattle, WA) was placed through the abdominal wall in cases of early postoperative chemotherapy intraperitoneally (EPIC) is expected. Otherwise, the catheter was placed on the midline incision abdominal Tenckhoff for use in HIIC. The Tenckhoff catheter functioned as a line flow. The closed suction catheters have been used as drainage lines for intraoperative lavage and remained in place for postoperative abdominal drainage. Two temperature sensors (Respiratory Support Products Inc., Irvine, CA) were then placed on the edge of the abdominal incision. A temperature sensor is connected to the catheter Tenckhoff. The other temperature sensor was attached to a closed suction drain at a location remote from the Tenckhoff. All tubes were transabdominal attached to the skin and peritoneum with sutures purse string to prevent leakage of fluid. The Thompson retractor (Thompson Surgical Instruments, Traverse City, MI) was then repositioned as in Figure 2. The abdomen was left open with the edges of the skin suspended in the reel Thompson with a number 2 running nylon suture. To avoid overflow of chemotherapy and chemotherapy to control vapors potential, a plastic sheet was sutured to the edges of the wound. An incision was then slit at the center of the sheet of plastic to allow the surgeon access to all surfaces of intra-abdominal and manually control the distribution of fluids. After hyperthermic perfusion was complete, intestinal anastomoses and other reconstructive procedures were performed.
Hyperthermic perfusion with mitomycin.
