Posted on February 27, 2010.
The advantages and disadvantages of chemotherapy to high-risk? The advantages and disadvantages of chemotherapy to high risk:
Take the case of someone who has been diagnosed with chronic myeloid leukemia (CML). This person has responded well to the first oral chemotherapy and CML entered a phase of latency. However, at this point his oncologist outlines its future options. He could not continue with interferon alpha and CML could remain in its latent stage for years, but there is no way of knowing how long it would last phase of latency. Or if he wants to be cured, it could have high dose chemotherapy and stem cell transplantation. It is a very aggressive treatment is the only proven treatment to cure CML. However, the risk of this treatment is important and it is not inconceivable that he could die from the treatment itself. Is there a moral reason PERF course of treatment over the other?
There is no moral element of the stem cell transplant. The stem cells used come from an adult donor and will be the bone marrow or peripheral stem cells. The stem cell is essentially a bone marrow transplant. They call it a stem cell transplant today, however, because the same type of stem cells in marrow that are the work of the Registry are also present in the circulating blood and cord blood. Peripehral blood stem cells are the cells most often used in transplantation.
The treatment is risky. People do not die to go through it, I usually layer. But many people go through it, survive, and never look back.
I had the transplant nearly two years ago for another type of leukemia, AML. I pretty much had no choice, such as acute leukemias progress and kill more rapidly than chronic leukemia. If he opts for the transplant, they will ensure that you are healthy enough to go through it also. It will be in hospital for six weeks, and in ambulatory care per day for six weeks, and it takes about a year or more to fully recover. I had complications with GVHD, if in two years, I'm still recovering.
The biggest risk is infection. It has high-dose chemotherapy and possibly radiation from the solid body. The purpose of this is to kill his spinal existing (where CML originates), so there is room for transplantation. However, as the spinal form the immune system, it will have no immune system to a maximum of a few weeks until the new cells to be transplanted. It would be in isolation and in an intensive care unit to minimize these risks, but they are there and they are high.
There are other risks such as graft against the host of complications with the reproductive system (the Registry by me ... menapause at age 23).
It should have a consultation with his apt docs and discuss the possibility of a transplant and what it entails and the specific risks related to his case. It must also ensure that the transplant has a great hospital that the transplant on a reg.
The decision to pursue a course of therapy rather than another is a personal decision and the decision of a patient. This is an informed decision made with full knowledge of the risks and benefits known. If a doctor can outline a therapy and identify all the risks and benefits, no doctor can make the right choice for a patient. And all patients have the right to reject any or all forms of treatment. So, since this is a decision taken by the patient, I do not see how morality plays in it.