Posted on March 4, 2010.
Inhibitors of proton pump-drug Drug Type
inhibitors proton pump (PPLS) gastric (stomach) of acid secretion inhibitors.
How the drug works
PPLS significantly reduce gastric acid secretion and for a prolonged period by blocking the final step of acid production by the lining of the stomach.
Uses
For the short term treatment (8 weeks or less) of the disease Gastroesophageal reflux disease (GERD, reflux of stomach contents into the esophagus, which can cause heartburn), and to maintain healing and reduce relapse rates of heartburn symptoms in patients with erosive or ulcerative GERD.
Esomeprazole, lansoprazole, omeprazole for the treatment of short-term (4-8 weeks for esomeprazole and omeprazole, 8 weeks or less for lansoprazole) or continue the healing of inflammation and erosion of the food pipe (erosive nsophilqitis).
Esomeprazole, lansoprazole, omeprazole, rabeprazole: in combination with antibiotics for the treatment and eradication of Helicobacter pylori infection and associated active duodenal ulcer and reduce the risk of ulcer recurrence .
Lansoprazole: In the short term treatment (up to 12 weeks) to reduce the risks associated with NSAID gastric ulcers.
Lansoprazole, omeprazole for the treatment of short-term (4-8 weeks for omeprazole, 8 weeks or less for lansoprazole) assets benign gastric ulcers, to treat and reduce the risk of gastric ulcers associated the use of anti-inflammatory drugs (NSAIDs) (Iansoprazole only).
Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole: For long-term treatment of hypersecretory (increased acid secretion) conditions (eg, Zollinger-Ellison syndrome).
Lansoprazole, Omeprazole, Rabeprazole: For short-term treatment (4-8 weeks for omeprazole, four weeks or less for lansoprazole, rabeprazole) of active duodenal ulcer, to maintain healing of duodenal ulcers (Iansoprazole only).
Other Uses: These agents may increase the effectiveness of pancreatic enzyme replacement used to treat fecal "fat" of patients with cystic fibrosis. Omeprazole was prescribed to treat laryngitis.
Pregnancy: There are no adequate and well controlled studies in pregnant women. Use only when absolutely necessary and the potential benefits to assess the potential risk to the fetus.
Lactation: It is not known whether inhibitors of proton pump are excreted in breast milk. Because of the risk of serious adverse reactions in infants PPI, decide to discontinue nursing or the drug, taking into account the importance of the drug to the mother. Consult your doctor before you begin breastfeeding.
Children: Omeprazole can be used in children 2 years and older.
The safety and efficacy of other agents have not been established.
Drug Interactions
Tell your doctor or pharmacist if you are taking or plan to take over the counter or prescription medications or dietary supplements with these drugs. doses of medication may be necessary to change or a different drug prescribed. The following drugs and drug classes interact with these drugs:
Ampicillin (eg Principen)
Clarithromycin (eg, Biaxin)
Benzodiazepines (eg diazepam)
Cyclosporine (eg, Neora /)
Disulfiram (eg, Antabusn)
iron salts (eg ferrous sulfate)
Phenytoin (eg, Dilantin)
Sucralfate (eg, Carafate)
Adverse
Every drug can produce side effects. Many patients experience no, or minor side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy and individual susceptibility ..
